Professor James Ware

James is a Professor of Cardiovascular and Genomic Medicine at the National Heart & Lung Institute, Imperial College London; Programme Leader at the MRC Laboratory of Medical Sciences; honorary Consultant Cardiologist at Royal Brompton Hospital and Hammersmith Hospital; and a Visiting Scientist at the Broad Institute of MIT & Harvard. He graduated from the University of Cambridge, trained clinically in London & Geneva, and pursued research training at Imperial College London, Harvard Medical School, and the Broad Institute, before starting a research group at Imperial.

Clinical interests include the management of Inherited Cardiac Conditions, the prevention of sudden cardiac arrest, and the broader application of genetics and genomics to healthcare.

James’ research aims to understand the impact of genetic variation on the heart and circulation, and to use genome information to improve patient care. Working with collaborators in the UK and internationally, his team are identifying new genes and pathways underlying inherited cardiovascular conditions, developing tools to discriminate between pathogenic and benign genetic variation, evaluating genomic biomarkers for precision medicine, and developing and testing new genetic therapies.

James is also Director of the national MRC/NIHR funded Rare Disease Research UK Cardiovascular Initiative, co-leads the NIHR-BHF Cardiovascular Partnership Theme in rare and genetic cardiovascular disease, co-leads the cardiovascular theme of the NIHR Imperial Biomedical Research Centre, and founded theHeartHive.org research participation portal in partnership with the patient charity Cardiomyopathy UK.